Effect of Vitamin E on Uroepithelial Cells
and Changes of Urinary Sediments in
Oncology Hospital Nursing Personnel
Published: November 1, 2013 | DOI: https://doi.org/10.7860/JCDR/2013/.3614
Majid Rezaei-Basiri, Hassan Rezazadeh, Iraj Asvadi-Kermani,Mahmud Ghazi-Khansari, Mehri Golchin, Mojgan Sarmad
1. Research Scholar, Department of Pharmacology and Toxicology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz-Iran.
2. Associate Professor, Department of Pharmacology and Toxicology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz-Iran.
3. Professor, Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz-Iran.
4. Professor, Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran-Iran.
5. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz-Iran.
6. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz-Iran.
Correspondence
Dr. Hassan Rezazadeh,
Associate Professor, Department of Pharmacology and Toxicology, School of Pharmacy, Tabriz University of Medical Sciences / Iran.
Phone: +98 - 411 – 3341315, Fax: +98 - 411 – 3344798, E-mail: rezafar81@hotmail.com
Introduction: Vitamin E is an important natural antioxidant, and its most common and biologically active form is a-tocopherol. The antiproliferative effects of alpha-tocopherol have been previously demonstrated. In this study we investigated the effects of vitamin E on urinary epithelial cells and urinary sediments of nursing from oncology hospital.
Material and Methods: Sixty-two female nursing personnel from oncology hospital participated in the study. They received orally 200mg of vitamin E per day for two weeks. Also prior to vitamin E and after vitamin E administration, the uroepithelial cells counts and other components of urinary sediments were carried out.
Results: There were significant differences in the epithelial cells count and treatment with vitamin E causing significantly more number of epithelial cells and urinary sediments to be excreted in the urine.
Discussion: Vitamin E significantly plays an important role on the excretion of uroepithelial cells and urinary sediments.
Conclusion: In conclusion we propose that use of vitamin E at nontoxic levels would significantly enhance its antioxidative properties, especially among individuals subjected to prophylaxis of occupational hazards
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